Denison Library’s Special Collections are extensive and varied, ranging from classical literature to Californiana. They include the Scripps College Archives, which provide a significant record for the study of the college since its inception in 1926 and for the history of women’s education in general.

The Yosemite Archives contain historical records and manuscripts related to Yosemite's history, including the donated papers of ethnographers and scientists, resource management records, historic park administrative records, and slide, photo, and film collections.