The Museum exhibits American Indian cultural materials, primarily focused on cultures of the Southwestern, Great Basin and Californian culture regions, which were connected by a major trade route from circa 4,000 BP. One of the largest collections is from the California coast and Channel Islands. Seven thousand artifacts are represented, ranging in age from 8-9,000 BP to ethnographic/historic…

The Homestead Museum collection includes a diverse array of items from Los Angeles and the Los Angeles Region covering the general period of 1830 to 1930 and includes ephemera, maps, photographs, printed works, and three-dimensional everyday artifacts. The Homestead Museum is a participant in the LAAS and ONE Archives Hidden Histories project.